Effect of Hyperbaric Oxygen Therapy on Healthy Volunteers Microcirculation
Microcirculation alterations and hyperoxia are known to alter ICU-patients’ prognostic.
Studies have shown that hyperoxia alters healthy volunteers’ microcirculation, whereas
hyperbaric oxygen therapy is commonly used to facilitate cicatrization. There seems to be a
paradox. A recent study in rabbits has given some evidences that hyperbaria may restore
microcirculation integrity, but to date, there is no such evidences in human.
To study hyperoxia and hyperbaric induced changes in micro and macrocirculation, fifteen
healthy volunteers will be exposed to successive variations of inspired oxygen fraction and
barometric pressure according to a predefine sequence so that only one parameter will change
from a condition to the next one :
1. FiO2 0.21 – 1 ATA
2. FiO2 1 – 1 ATA
3. FiO2 1 – 2.5 ATA
4. FiO2 0.21 – 2.5 ATA
5. FiO2 0.21 – 1 ATA
At each time, and after a 30 minutes period of exposure, measures will be made using
SDF-microscopy, Laser Doppler and NIRS to assess microcirculation.
As previously described, macrocirculation can modify microcirculation due to a mechanism
called hemodynamic coherence.
Hence, the investigators planned to assess macrocirculation changes at every step of the
protocol using bioimpedancemetry and transthoracic echocardiography.
Each volunteer will be his own control, using the first measurements (condition 1. FiO2 0.21
– 1 ATA) as reference.
Hyperbaric Oxygen Therapy
Hyperbaric oxygen therapy
June 14, 2019
University Hospital, Lille
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