Middle ear barotrauma (MEB) is the most common complication during hyperbaric oxygen therapy
(HBOT). Though Valsalva and Toynbee maneuvers have been proposed to prevent MEB, still some
patients discontinue HBOT due to severe otalgia, hemorrhage or perforation of tympanic
membrane associated with HBOT. Currently, there is no optimal prophylactic management for MEB
associated with HBOT. The aim of this protocol is to investigate the efficacy of
self-acupressure therapy on MEB associated with HBOT.
The aim of the current study was to examine the effect of short-term HBOT (hyperbaric oxygen
treatments) on a range of cognitive abilities. The current study examined whether there is a
HBOT-related short-term cognitive improvement and, if so, what specific cognitive abilities
are improved by the intervention.
Participants were randomized to perform cognitive tasks in one of two chambers with two
different clinical environments: (a) HBOT condition: (2 ATA (atmosphere absolute) 100% oxygen
for 90 minutes). (b) Control condition: in which the chamber was not pressurized (Normobaric
condition- 1 ATA for 90 minutes).
Previous studies shoes that hyperoxia alters microcirculation.The investigators hypothesize
that hyperbaric may restore microcirculation integrity. This hypothesis is supported by a
recent study in rabbits, but no data exists for humans.
The study will expose fifteen healthy volunteers to a succession of different fraction of
inspired oxygen and barometric pressure and assess microcirculatory and macrocirculatory
changes via sidestream dark field videomicroscopy, near-infrared spectroscopy, Laser Doppler,
transthoracic echocardiography and bio-impedancemetry at every step.
The investigators want to evaluate the short duration HBOT can improve glycohemoglobin
(HbA1c) levels, leukocyte count, and serum creatinine levels in patients with DFU (diabetic
foot ulcer) Wagner 3-4.
Due its high incidence, mTBI and its consequences of PPCS are a major public health issue.
There is no consensus regarding the treatment of PPCS in pediatrics. Relying on its results
in adults, HBOT offers a promising new direction of treatment, which targets the basic
pathological processes responsible for post-concussion symptoms.
The effect of hyperbaric oxygen therapy in pediatric TBI has never been evaluated.
The aim of the current study is to evaluate in a prospective cross-over, randomized study,
the effect of HBOT on children with PPCS due to mild TBI.
In our institute there is ongoing treatment of brain injury patients with Hyperbaric oxygen
therapy. These patients undergo neuro-cognitive function tests in addition to brain imaging
studies before and after treatment.
The aim of this study was to evaluate the perfusion and microstructure changes seen in MRI in
addition to the cognitive tests before and after the treatment.