Chronic

Clinical Trial – Hyperbaric Oxygen for Traumatic and Non-traumatic Brain Injury

The purpose of this study is to examine whether 40 hyperbaric oxygen sessions has effect on
long-term symptoms after brain injury. This study will enroll 90 individuals with persistent
problems 6 months to 10 years after a brain injury. These individuals will be randomized to
receive either oxygen or air in a pressurized hyperbaric chamber. Participants will receive
40 daily hyperbaric chamber sessions.

Participants will have a series of tests and questionnaires before they begin their chamber
sessions, after they complete 40 sessions, and 6 months after they joined the study. These
tests include computer-based and pencil-and-paper questionnaires and thinking tests, brain
imaging, a neurological examination, and an eye exam. Participants will also be asked to
provide blood for future research.

After the 6-month tests are complete, all participants will receive 40 hyperbaric oxygen
sessions, then undergo the same tests at 9 months and 12 months.

Clinical Trial – Treatment of Traumatic Brain Injury With Hyperbaric Oxygen Therapy

The purpose of this study is to determine if hyperbaric oxygen therapy (HBOT) improves the
cognitive function of OIF/OEF individuals who have chronic mild to moderate traumatic brain
injury (TBI). Cognitive function includes such things as thinking, remembering, recognition,
concentration ability and perception. Traumatic brain injury is common with head injuries
caused by blows to the head, nearby explosions, or concussion. Subjects will be assigned to
an intervention or sham arm. Computer based cognitive tests will be used as outcome measures.
Subjects are enrolled by invitation only.