HBOT News host, Edward di Girolamo asks you to take 2 minutes to listen to this Special Report.  His passion and energy for this topic can be immediately seen as he explains the best way to reduce and eliminate inflammation in the body.  di Girolamo has reaped all the known benefits of Hyperbaric Oxygen Therapy (HBOT) & water fasting since he has done it for years and is currently in the middle of a 10-day water fast.  He urges everyone to know this information and reap the benefits of longevity by combining Hyperbaric Oxygen Therapy and extended water fasting.

Tucked away in Research-Triangle Park of Raleigh, NC is a HBOT clinic that is challenging the community to start their New Year out with a total body reset.  Extivita-RTP, combines the two most power anti-inflammatory therapies known — HBOT and water fasting — with fellowship, fun, and accountability to help the participants excel and succeed in their weight loss and health goals. They call it the Longevity Challenge and is running the 12-day challenge from January 8-20, 2023.

To support the benefits of water fasting, we’ve pulled all the best research.

Water fasting alone is a total body cleansing that can date back to the 5th century.  But, when you combine water fasting and HBOT, truly miraculous things happen in the human body. We invite you to participate with many of us here at HBOT News as we also compete in the Longevity Challenge, and start 2023 off with a natural and holistic way to achieve optimum health and wellness.

 

Research

  1. Anton SD, Moehl K, Donahoo WT, Marosi K, Lee SA, Mainous AG 3rd, Leeuwenburgh C, Mattson MP. Flipping the Metabolic Switch: Understanding and Applying the Health Benefits of Fasting. Obesity (Silver Spring). 2018 Feb;26(2):254-268. doi: 10.1002/oby.22065. Epub 2017 Oct 31. PMID: 29086496; PMCID: PMC5783752. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5783752/  
  2. Dąbek A, Wojtala M, Pirola L, Balcerczyk A. Modulation of Cellular Biochemistry, Epigenetics and Metabolomics by Ketone Bodies. Implications of the Ketogenic Diet in the Physiology of the Organism and Pathological States. Nutrients. 2020 Mar 17;12(3):788. doi: 10.3390/nu12030788. PMID: 32192146; PMCID: PMC7146425. https://pubmed.ncbi.nlm.nih.gov/32192146/  
  3. Berg JM, Tymoczko J, Stryer L. Biochemistry. 5th edition. New York, NY: W. H., and Freeman; 2002. Section 30.2, Each Organ Has a Unique Metabolic Profile; (2002). Available online at: https://biokamikazi.files.wordpress.com/2013/10/biochemistry-stryer-5th-ed.pdf
  4. Mattson MP, Longo VD, Harvie M. Impact of intermittent fasting on health and disease processes. Ageing Res Rev. 2017 Oct;39:46-58. doi: 10.1016/j.arr.2016.10.005. Epub 2016 Oct 31. PMID: 27810402; PMCID: MC5411330. https://pubmed.ncbi.nlm.nih.gov/27810402/  
  5. Alirezaei M, Kemball CC, Flynn CT, Wood MR, Whitton JL, Kiosses WB. Short-term fasting induces profound neuronal autophagy. Autophagy. 2010 Aug;6(6):702-10. doi: 10.4161/auto.6.6.12376. Epub 2010 Aug 14. PMID: 20534972; PMCID: PMC3106288. https://pubmed.ncbi.nlm.nih.gov/20534972/  
  6. Bagherniya M, Butler AE, Barreto GE, Sahebkar A. The effect of fasting or calorie restriction on autophagy induction: A review of the literature. Ageing Res Rev. 2018 Nov;47:183-197. doi: 10.1016/j.arr.2018.08.004. Epub 2018 Aug 30. PMID: 30172870. https://pubmed.ncbi.nlm.nih.gov/30172870/  
  7. Pietrocola F, Demont Y, Castoldi F, Enot D, Durand S, Semeraro M, Baracco EE, Pol J, Bravo-San Pedro JM, Bordenave C, Levesque S, Humeau J, Chery A, Métivier D, Madeo F, Maiuri MC, Kroemer G. Metabolic effects of fasting on human and mouse blood in vivo. Autophagy. 2017 Mar 4;13(3):567-578. doi: 10.1080/15548627.2016.1271513. Epub 2017 Jan 6. PMID: 28059587; PMCID: PMC5361613. https://pubmed.ncbi.nlm.nih.gov/28059587/  
  8. Vendelbo MH, Møller AB, Christensen B, Nellemann B, Clasen BF, Nair KS, Jørgensen JO, Jessen N, Møller N. Fasting increases human skeletal muscle net phenylalanine release and this is associated with decreased mTOR signaling. PLoS One. 2014 Jul 14;9(7):e102031. doi: 10.1371/journal.pone.0102031. PMID: 25020061; PMCID: PMC4096723. https://pubmed.ncbi.nlm.nih.gov/25020061/ 
  9. Martin DD, Ladha S, Ehrnhoefer DE, Hayden MR. Autophagy in Huntington disease and huntingtin in autophagy. Trends Neurosci. 2015 Jan;38(1):26-35. doi: 10.1016/j.tins.2014.09.003. Epub 2014 Oct 2. PMID: 25282404. https://pubmed.ncbi.nlm.nih.gov/25282404/  
  10. Escobar KA, Cole NH, Mermier CM, VanDusseldorp TA. Autophagy and aging: Maintaining the proteome through exercise and caloric restriction. Aging Cell. 2019 Feb;18(1):e12876. doi: 10.1111/acel.12876. Epub 2018 Nov 15. PMID: 30430746; PMCID: PMC6351830. https://pubmed.ncbi.nlm.nih.gov/30430746/  
  11. Schwalm C, Jamart C, Benoit N, Naslain D, Prémont C, Prévet J, Van Thienen R, Deldicque L, Francaux M. Activation of autophagy in human skeletal muscle is dependent on exercise intensity and AMPK activation. FASEB J. 2015 Aug;29(8):3515-26. doi: 10.1096/fj.14-267187. Epub 2015 May 8. PMID: 25957282. https://pubmed.ncbi.nlm.nih.gov/25957282/  
  12. Hartman ML, Veldhuis JD, Johnson ML, Lee MM, Alberti KG, Samojlik E, Thorner MO. Augmented growth hormone (GH) secretory burst frequency and amplitude mediate enhanced GH secretion during a two-day fast in normal men. J Clin Endocrinol Metab. 1992 Apr;74(4):757-65. doi: 10.1210/jcem.74.4.1548337. PMID: 1548337. https://pubmed.ncbi.nlm.nih.gov/1548337/  
  13. Amole N, Unniappan S. Fasting induces preproghrelin mRNA expression in the brain and gut of zebrafish, Danio rerio. Gen Comp Endocrinol. 2009 Mar;161(1):133-7. doi: 10.1016/j.ygcen.2008.11.002. Epub 2008 Nov 8. PMID: 19027742. https://pubmed.ncbi.nlm.nih.gov/19027742/ 
  14. Rudman D, Feller AG, Nagraj HS, Gergans GA, Lalitha PY, Goldberg AF, Schlenker RA, Cohn L, Rudman IW, Mattson DE. Effects of human growth hormone in men over 60 years old. N Engl J Med. 1990 Jul 5;323(1):1-6. doi: 10.1056/NEJM199007053230101. PMID: 2355952. https://pubmed.ncbi.nlm.nih.gov/2355952/ 
  15. Aguiar-Oliveira MH, Bartke A. Growth Hormone Deficiency: Health and Longevity. Endocr Rev. 2019 Apr 1;40(2):575-601. doi: 10.1210/er.2018-00216. PMID: 30576428; PMCID: PMC6416709. https://pubmed.ncbi.nlm.nih.gov/30576428/ 
  16. Caicedo D, Díaz O, Devesa P, Devesa J. Growth Hormone (GH) and Cardiovascular System. Int J Mol Sci. 2018 Jan 18;19(1):290. doi: 10.3390/ijms19010290. PMID: 29346331; PMCID: PMC5796235. https://pubmed.ncbi.nlm.nih.gov/29346331/  
  17. Klein S, Sakurai Y, Romijn JA, Carroll RM. Progressive alterations in lipid and glucose metabolism during short-term fasting in young adult men. Am J Physiol. 1993 Nov;265(5 Pt 1):E801-6. doi: 10.1152/ajpendo.1993.265.5.E801. PMID: 8238506. https://pubmed.ncbi.nlm.nih.gov/8238506/  
  18. Gjedsted, Jakob & Gormsen, Lars & Nielsen, Søren & Schmitz, O & Djurhuus, Christian & Keiding, Susanne & Ørskov, H & Tønnesen, Else & Moller, Niels. (2007). Effects of a 3‐day fast on regional lipid and glucose metabolism in human skeletal muscle and adipose tissue. Acta physiologica (Oxford, England). 191. 205-16. 10.1111/j.1748-1716.2007.01740.x. www.researchgate.net/publication/6055419_Effects_of_a_3-day_fast_on_regional_lipid_and_glucose_metabolism_in_human_skeletal_muscle_and_adipose_tissue 
  19. Cheng CW, Adams GB, Perin L, Wei M, Zhou X, Lam BS, Da Sacco S, Mirisola M, Quinn DI, Dorff TB, Kopchick JJ, Longo VD. Prolonged fasting reduces IGF-1/PKA to promote hematopoietic-stem-cell-based regeneration and reverse immunosuppression. Cell Stem Cell. 2014 Jun 5;14(6):810-23. doi: 10.1016/j.stem.2014.04.014. Erratum in: Cell Stem Cell. 2016 Feb 4;18(2):291-2. PMID: 24905167; PMCID: PMC4102383. https://pubmed.ncbi.nlm.nih.gov/24905167/   
  20. Mattson MP, Moehl K, Ghena N, Schmaedick M, Cheng A. Intermittent metabolic switching, neuroplasticity and brain health. Nat Rev Neurosci. 2018 Feb;19(2):63-80. doi: 10.1038/nrn.2017.156. Epub 2018 Jan 11. Erratum in: Nat Rev Neurosci. 2020 Aug;21(8):445. PMID: 29321682; PMCID: PMC5913738.    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5913738/  
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