Phase 1 Study of Protective Effect of Hyperbaric Oxygen Preconditioning on Brain and Myocardium Injury During CABG Surgery
Description:
60 patients scheduled to undergo coronary revascularization were recruited for this trial.
Exclusion criteria included Emergency operation, age older than 80 years, learning
difficulty, previous cerebrovascular disease, visual or hearing impairment, history of
pneumothorax, Claustrophobia, middle ear disease, EF < 35%. Patients were randomized either
to the control group or hyperbaric oxygen group. The laboratory analysis of markers included
S100B, NSE and troponin I. The assessment of cognitive dysfunction was performed 5 days
before surgery and 7 days after surgery and haemodynamic measurements, length of stay in ICU,
length of stay in hospital post-operation were recorded.
Condition:
Brain Injury
Treatment:
Hyperbaric oxygen pretreatment (GR2200)
Start Date:
November 2007
Sponsor:
Xijing Hospital
For More Information:
https://clinicaltrials.gov/show/NCT00817791