Brain Angiogenesis Induced by Hyperbaric Oxygen Therapy Can be Visualized by Perfusion MRI in Brain Injury Patients


Retrospective analysis of patients suffering from chronic neuro-cognitive damage due to TBI
treated at Sagol center for hyperbaric medicine and research, Assaf Harofeh Medical Center,

Patients included if they had at least two perfusion MRIs + DTI and two neurocognitive tests,
before and after Hyperbaric Oxygen Therapy (HBOT). The study was approved by the
institutional review board of the hospital.

Patients are treated with 50-70 daily hyperbaric sessions, 5 days per week. Each session
consists of 60 minutes exposure to 100% oxygen at 1.5 ATA.

All patients that underwent MRI before and after HBOT. The MRI protocol included DSC, DCE,

MRI scans sequences parameters:

* DSC: 50 T2*-weighted gradient-echo echo planar imaging (EPI) volumes were acquired, 2
repetitions before a bolus injection of Gadolinium-DTPA (Gd-DTPA), 48 repetitions after
injection of Gd-DTPA. Sequence parameters: TR=2,300 ms, TE= 40ms, flip angle = 30°, voxel
size = 1.8 x1.8, Matrix = 128×128, No. of slices = 25, Slice thickness = 3.9 mm.

– DCE: three T1 weighted Fast Low Angle SHot (FLASH) volumes were acquired with different
flip angles (2, 7 and 15 degrees) followed by 70 dynamic T1 weighted FLASH volumes with
flip angle of 15 degrees after bolus injection of Gd-DTPA. Sequence parameters: before
injection: TR=4.09, after injection – TR=4.86 ms, TE= 1.76 ms, Voxel size = 1.5×1.5,
Matrix = 192X192, No. of slices = 26, Slice thickness = 3.5mm.

– DTI: 30 diffusion weighted images were scanned with different gradient directions
(b=1000) and one volume without diffusion weighting, with the following parameters:
TR=10,300 ms, TE=89 ms, Voxel size = 1.8X1.8, Matrix = 128 X 128, No. of slices = 63,
Slice thickness = 2.2mm


Hyperbaric Oxygen Therapy


Hyperbaric oxygen therapy

Start Date:

March 2015


Assaf-Harofeh Medical Center

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