Complementary therapy options are needed in the treatment of active ulcerative colitis (UC). Hyperbaric oxygen therapy (HBOT) has been shown to have positive effects in experimental models of colitis and perianal Crohn’s disease. In the present prospective randomized open-label study, HBOT in addition to conventional medical treatment was compared with conventional treatment alone. The primary objective in this study was improved clinical outcome evaluated by Mayo score, laboratory tests and fecal weight. The secondary objectives were improvement in health-related quality of life, avoidance of colectomy and evaluation of HBOT safety. The authors found no statistically significant differences between the treatment groups in any of the assessed variables.
Ulcerative Colitis (UC)
A favourable response to surgical intervention and hyperbaric oxygen therapy in pyoderma gangrenosum.
Pyoderma gangrenosum (PG) is a neutrophilic dermatosis characterised with ulcerations. Inflammatory bowel diseases (ulcerative colitis and Crohn’s disease) and haematologic diseases (leukaemia, preleukaemia and monoclonal gammopathy) have been reported in about 40-50% of PG patients in whom the treatment of the underlying disease is important for the improvement of the lesions. We herein report a colorectal adenocarcinoma patient with PG, who responded partially to topical treatments and systemic immunosuppressants and healed completely with the aid of surgical wound repair and hyperbaric oxygen therapy.
HBOT for inflammatory bowel disease
Traditionally, hyperbaric oxygen treatment (HBOT) has been used to treat a limited repertoire of disease, including decompression sickness and healing of problem wounds. However, some investigators have used HBOT to treat inflammatory bowel disease (IBD), including Crohn’s disease and ulcerative colitis.
Comprehensive searches were conducted in 8 scientific databases through 2011 to identify publications using HBOT in IBD. Human studies and animal models were collated separately.
Hyperbaric oxygen treatment for inflammatory bowel disease: a systematic review and analysis.
Traditionally, hyperbaric oxygen treatment (HBOT) has been used to treat a limited repertoire of disease, including decompression sickness and healing of problem wounds. However, some investigators have used HBOT to treat inflammatory bowel disease (IBD), including Crohn’s disease and ulcerative colitis. Comprehensive searches were conducted in 8 scientific databases through 2011 to identify publications using HBOT in IBD. Human studies and animal models were collated separately. Thirteen studies of HBOT in Crohn’s disease and 6 studies in ulcerative colitis were identified. In all studies, participants had severe disease refractory to standard medical treatments, including corticosteroids, immunomodulators and anti-inflammatory medications.
Hyperbaric oxygen treatment for inflammatory bowel disease: a systematic review and analysis.
Abstract: Traditionally, hyperbaric oxygen treatment (HBOT) has been used to treat a limited repertoire of disease, including decompression sickness and healing of problem wounds. However, some investigators have used HBOT to treat inflammatory bowel disease (IBD),...
Hyperbaric oxygen enhances the efficiency of 5-aminosalicylic acid in acetic acid-induced colitis in rats.
Abstract: The aim of this study was to assess the efficiency of hyperbaric oxygen alone and in combination with 5-aminosalicylic acid in the acetic acid-induced colitis model, a well-known experimental model of inflammatory bowel disease in rats. Rats were randomly...
Effect of hyperbaric oxygen on experimental acute distal colitis.
Abstract: It has been demonstrated that hyperbaric oxygen (HBO) is useful as an adjunctive therapy for Crohn's disease. However, its effects on ulcerative colitis have not been investigated. In the present study, HBO was tested for acetic acid-induced colitis, and...
A different therapeutic approach in patients with severe ulcerative colitis: hyperbaric oxygen treatment.
Abstract: Gürbüz, Elbüken, Yazgan, Yildiz, , , , , (2003). A different therapeutic approach in patients with severe ulcerative colitis: hyperbaric oxygen treatment. Southern medical journal, 2003 Jun;96(6):632-3. https://www.ncbi.nlm.nih.gov/pubmed/12938799
A different therapeutic approach in severe ulcerative hyperbaric oxygen treatment.
Abstract: Gurbuz, Elbüken, Yazgan, Yildiz, , , , , (2003). A different therapeutic approach in severe ulcerative hyperbaric oxygen treatment. Romanian journal of gastroenterology, 2003 Jun;12(2):170-1. https://www.ncbi.nlm.nih.gov/pubmed/12854005
Prophylactic high dose methylprednisolone fails to treat severe decompression sickness in swine.
Abstract: Controlled decompression from saturation conditions is not always an option, particularly in a disabled submarine scenario. Hypothesis Prophylactic high dose methylprednisolone (MP) would improve outcome in severe cases of decompression sickness (DCS)....